I guess it's my turn:
Yes, the Clone Wars are focused on in my prequels. The Clones are slave laborers and soldiers controlled by technologically advanced cyborg-machines with cloning technology. The Clones attack the Outer Rim territories in search of a lost artifact needed for the cloning process that would, in effect, save their race. The distrust of machines in the Outer Rim planets, such as Tatooine, is a result of the wars.
There are a series of wars which are bit complex. As the Outer Rim planets have no organized military they appeal to the Galactic Republic for military aid. The Galactic Republic Senate has almost become completely controlled by corrupt aristocracies left over from the Galactic Kingdom. These power-hungry aristocrats see this as an oppurtunity to control trade with the natural resource-laden Outer Rim planets, specifically Tibanna gas mining.
After a series of wars, the Republic armies are crippled and with the advice of certain corrupt Senators, Mandalorian pirates are hired as mercenaries to help finish the Clones in exchange for them being authorized to set up organized crime operations and control trade in the Outer Rim. Those Senators of course would, of course, have a hand in the pot. This backroom deal is sold to the moral Senators as a last ditch effort liberating force.
After these events the Outer Rim territories are in bad shape as they no longer have any standard of living or control of their own well-being. Gangsters and corrupt politicians have total control in the territories of disenfranchised aliens and refugee clones. Without rights, the outer planets can only protest and retaliate in the form of terrorism which creates animosityand xenophobia between those planets and the Galactic Republic.
After the assassination of the populist Chancellor of the Republic by a group of political conspirators, the Senator who assumes power enacts new laws made to combat terrorism along with totally replacing the destroyed Republic armies. The new Chancellor, through executive orders, makes himself Emperor and attacks the terrorist cells in the Outer Republic, thus completely taking over the entire galaxy as sole ruler.
Continuity to the OT:
All surprises are left intact in the trilogy. Characters like Yoda are mentioned but never seen and do not have large roles. Anything said in the OT to be true, is. The episodes are meant to be seen in order.
The Sith are involved in the wars and heavily influence them as well as Anakin's turn to the Dark Side. They are sworn enemies of the Jedi and resurface after many years from their defeat in the Jedi-Sith war which took place during the times of the Galactic Kingdom. The Jedi have not been an organized council since after the Sith were defeated.
Palpatine is not a Sith. There are force-users who are not Jedi and not Sith. There are no rules of two, or rules against attachment or specific dress for Jedis. The Jedi do not operate in the traditional ways of the past when the force was religion.
The droids are owned by King Organa and are in the prequels. Obi-Wan, Amidala (not Padme), and Anakin are the main protagonists.
(I'll add this later. No time. But this is important.)