My guesses for the two reasons:

Reason #1: This is the easy one. Just the simple Hitchhiker’s Guide reference.

Reason #2: A slightly more abstruse Hitchhiker’s Guide reference. One very nice explanation for how 42 could actually be The Answer was that “To Be or Not To Be” is The Question, and could be written as “2B || !2B”, which in hexadecimal, means “43 or not 43”. The answer being 42 means that the answer to “To Be or Not To Be” is “Not To Be”. Which, very cleverly, also answers the thread title.

Nice job, Frink.