Unfortunately there’s really not much doubt about the dislike of the Ghostbusters trailer being due at least in part to misogyny.
Beloved movies/franchises getting reboot/remakes are far from something new (and neither are bad trailers). The volume here is telling (not to mention the comments).
Or perhaps it’s because it wasn’t funny. Literally none of the jokes in the trailer hit, for me at least. It wasn’t necessary to reboot Ghostbusters in the first place, and people always complain when movies are rebooted. It just doesn’t help that they’re rebooting a beloved comedy.