Unfortunately there’s really not much doubt about the dislike of the Ghostbusters trailer being due at least in part to misogyny.
Beloved movies/franchises getting reboot/remakes are far from something new (and neither are bad trailers). The volume here is telling (not to mention the comments).
Where was the massive backlash against TFA? I know some racist and misogynist fools came out and complained, but the trailers were received positively. The Ghostbusters trailer was received poorly because it was an unfunny trailer.