Might be able to. My other Memory Stick hardware works fine (digicam). The Mac has no problem whatsoever recognizing the Memory Stick for just what it is without any software installation. I just plug the camera directly in to my USB port and whammo! There is the Memory Stick icon on the desktop. But it may not be much of a concern since I've got a PC at work, too. Can hook up the PDA to the PC at work. I was just wondering if I'd be able to sync from home as well.