Even if the structural integrity of the Sulcaco could be maintained and that Ripley’s foot/arm didn’t snap and all the air wasn’t pulled out of the lungs of the humans particularly Newt screaming at the top of her voice, there is the small detail of all that radiation coming out of the vent open to space.
They would all die of cancer.
Remember that scene from that one movie called the Empire Strikes Back when the lead characters get off of the space ship on an asteroid and walk around with the cheap little masks that they give you when a plane cabin depressurizes, and there is no change of gravity whatsoever? That ruined the whole movie for me.