To make a Blu-ray compliant encode at excellent quality, these are the only settings you need. This will likely produce an encode larger than BD-25 with audio included. Note, this assumes your source material has already been converted to YV12 4:2:0.

–profile high --preset placebo --level 4.1 --bluray-compat --crf 16 --deblock -3:-3 --aq-strength 0.7 --no-mbtree

If you are aiming for BD-25 you should use 2-pass encoding instead of CRF in order to take full advantage of the space available. You can use various bitrate calculators to determine within a small margin of error what your target bitrate will need to be to hit the size constraint with any audio and subtitle tracks included. I recommend the calculator included with MeGUI as it can be configured to take into account overhead of various video and audio containers.