My money is on the adventures of the Enterprise J in the 26th century. That way they stay in the prime universe, but are far enough away from the previous shows, (the way TNG was from TOS) to be a fresh take on things.
They’ll find a way for Data or Q to show up of course. 😉
B4 you mean? Data bit the dust.
On a side note, I still firmly believe that movie was solid, if a bit strange.