I think games should follow the "comedy killer" rule: can you do a joke about a certain topic without completely offending an audience? If you can, than you might do a game about it.

You can make a joke about Hitler being anally raped and killed, so you can do a game about it.
You can't do a joke about the challenger explosion, so you can't make a game out of it.

But I do belive that JFK reloaded softwarehouse, Traffic, might release a 9-11 version to show that it was indeed possible to fly those planes, and that there was no conspiracy on it.