DrDre said:
I think one 2014 Nobel prize winner would disagree:
http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2014/advanced-chemistryprize2014.pdf
Keeping in mind that I'm a biologist and we sometimes use these techniques (TIRF, STED, STORM) but don't really properly understand them the way a physicist would:
I really don't follow how you're suggesting these specific techniques used for improving the resolution of fluorescence microscopy are related to enhancing images with a fixed number of pixels. Can you please explain? And to what technique specifically are you comparing it to? Temporal tricks like STORM, but across multiple frames rather than relying on the 'flickering' of fluorophores?