pretty much all of the officers came up through the ranks in the war and have the mindset of combat troops seeing everything as a threat plus they will have to get along with races they were fighting in the war,the central question will be how do you ask these people to move from a war mindset to a mission of peace.

I DO like this idea but they did kind of touch on that stuff already in Star Trek 6 -

Gorkon said: You don't trust me, do you? I don't blame you. If there is to be a brave new world, our generation is going to have the hardest time living in it.

So the only superpowers are the Federation and the Romulan star empire...and then Romulus is destroyed by the Hobus star, right?

What happnes next could be very interesting...or very boring.

The Gamma Quadrant is largely a blank canvas at this point, so setting something there could prove interesting, or at least fresh.

One thing we often see in Star trek is a crew of Humans with one or two aliens in the mix.

What if we were to flip things around and have a token 'human' that is the odd man out.

Would that be an interesting enough premise?