It is annoying that George couldn't make it line up with the preexisting OT, but, if I were to change anything when it comes to Padme's fate, it would be the line in ROTJ. In that film, the line is rather inconsequential. I disagree that it;s a big deal. I could have been, maybe even should have been. But it's one line that barely factors into the conversation Luke and Leia are having. If you took the line out, the film is practically the same.

In ROTS, however, Padme's death is the source of much genuine emotional power, and is one of the film's strongest aspects. It's what really makes Anakin's story a tragedy. If you took it out, you would be making the film worse.