"What is mind? No matter. What is matter? Nevermind!" - Homer Simpson

"The politics of failure have failed. We need to make them work again." - Kang disguised as Bob Dole

"Your indolence is inefficacious!" - Charles Montgomery Burns

Now, for some non-Simpsons quotes.

"Reality is that which, when you stop believing in it, doesn't go away." - Philip K. Dick

"It is sometimes an appropriate response to reality to go insane" - Philip K. Dick

"I could be bounded in a nutshell, and count myself a king of infinite space, were it not that I have bad dreams." - Hamlet

"I am very proud, revengeful, ambitious; with more offenses at my beck than I have thoughts to put them in, imagination to give them shape, or time to act them in." - Hamlet