March 22:
A.D. 1457: The Gutenberg Bible becomes the first printed book.
For some reason I thought I covered that already...maybe it was Gutenberg's invention of the printing press.
A.D. 1622: The first massacre of Europeans in America by the Powhattan tribe. 347 colonists are killed in Jamestown, Virginia.
A.D. 1765: The Stamp Act is passed and the first direct tax by the British government on American colonists is imposed.