The primary issue I'm running into now is that my computer isn't sufficiently powerful and I don't have the funds to build a better one.
It runs PFClean fine when I feed it SD material, but stepping up to HD material makes each and every little operation take that much longer.
Restoration is an experimental process, so most of the work involves applying a transformation, stepping through many frames to see if it was an acceptable one (e.g., no artifacts), and then repeating the process over again when you realize that it wasn't (this is usually the case).
When it takes ~1 minute to preview a frame... well, you get the idea.