I have to say that, as a moderate fan of the PT, I wish that the whole concept of the clones had played out differently. Now you may know I am a fan of TCW and see it as the redemption of the PT, but I can't help but feel like this should have been handled differently.
First, I would never have made droids such effective fighters. Why would any army utilize organic soldiers when droids would be cheaper and ultimately more powerful? A droid requires no eating, no sleeping, only recharging (which is cheap). A droid could be programmed in a very short time and then would be ready for battle. A droid could be outfitted with multiple appendages, could be programmed with superior reflexes, dexterity, strength, and precision in attack and firing (not demonstrated on screen, but if taken to a logical conclusion), and could receive regular software and hardware upgrades. A droid could continue fighting in spite of injury, would not experience fear, could communicate internally with numerous other units simultaneously to coordinate efforts, and could be provided with additional sensory equipment.
Meanwhile, clones take feeding, training (even with some imprinted instincts or whatever, the human brain still requires adjustment to unfamiliar physical maneuvers), entertainment, sleep. All clones are physically the same, and cannot be largely improved (i.e. no extra arms). The human brain, for all its creativity, is very limited by fear, imperfect calculation, normal human senses, etc. The technology to create them is newer and definitely costlier to create them. Clones are weaker and more expensive!
I understand the theory that sentient beings are more clever and innovative, thus offering an advantage, but I can hardly believe that such would offset the disadvantages. George Lucas would have done better to make sentient beings the primary fighting force as they are in the OT. Viewers would continue to assume that the technology to make an effective automaton army was simply not existent, as they always had.
Second, clones raise big moral issues. Bingowings has argued very interestingly about the morals of subjugating sentient artificial intelligences. But while the morality of that remains debatable, I find no gray area on creating new life forms for the sole purpose of sending them to fight and die against a military comprised entirely of robots. They get no opportunity to choose their path, have no hope for a better future. They are literal slaves to the "noble" Republic. Who raises this issue during the films? No one. The wonderful and good Jedi do not hesitate to immediately make use of them, and the people of the Republic approve of their purpose. Obi-wan never seems to feel bad about it (though in the novel he seems horrified when he first hears about them...for a few moments). Yoda himself brings them to Geonosis. And the Republic never attempts to create an army of machines to counter: rather they continue to waste life and money while simply draining the Separatists' population remains largely uninvolved.
I would never have involved robot armies. I wouldn't mind seeing a few AI assassins or special units, but never entire armies. I would rather have seen clones being used by the bad guys, or perhaps clones being used on both sides with an acknowledgement that such abuse was a portion of the atrocities committed on both sides of the war(s). Its lasting moral implications still would permeate to the time of ANH, obviously. I would have also included normal divisions so that the general population would feel the effects of the war, seeing their loved ones go off to die. Instead, the war must have been very depersonalized for most people on both sides, as nobody they cared about ever went off to fight except a few in leadership positions. And since they were called the Clone Wars (plural), it might have been nice to see ongoing fighting interrupted by brief intermissions of peace. To me, the Clone Wars would have been much more interesting, realistic, and less morally ambiguous if shown like this.