After playing Bioshock 1 and quite a bit of Infinite (I've been told by loads of friends to steer clear of 2, as they don't think it's particularly good) I was thinking that maybe a Bioshock game set in space might be fairly good, even though it kind of already exists in the form of 'System Shock'.

You could set it in the 1970s and have the player character somehow get to a base on the moon (maybe by a lighthouse that is actually a rocket, I dunno)

When you arrive on the base the political angle this time could be a more extremist version of Early World War 2 Britain (rationing, attitudes that were prevalent during the time, evacuation, patriotism, less Dieselpunk more... I dunno WW2-punk???) Although come to think of it, maybe that'd just be more of the same compared to the first two Bioshock games.

Considering the fact that the Bioshock games seem to have an element of deconstruction going in in them, maybe if there's another Bioshock game it serve as a reconstruction of the elements that the other games had previously deconstructed.