Thanks for the reply, AntcuFaalb.
He is not very computer-savvy, and I found out yesterday he doesn't even have virus or firewall protection. He ran with a bad crowd in high school, petty criminals, drug abusers, etc. He's convinced that a couple of these guys are perpetrating this attack against him to ruin him. It is, at least theoretically, possible that someone has gotten access to his computer through a virus or trojan (although I've yet to see any evidence of this). But it seems like a lot more work than just typing some mean stuff about a person. We're talking about creating an entirely fake Facebook with all the image and status displaying technology of Facebook. Seems as unlikely as someone hacking the MSNBC news feed.
I've spoken with his doctor, and he thinks it's more likely that we're seeing an underlying delusional disorder coming to the surface. The next step will be prescribing an anti-psychotic for a few days to see if that helps.