An American Tail. I'm serious about this one. The 5.1 DVD remix is semi-notorious for being altered from the original Dolby Stereo. As with Superman, they added sound effects and they are sometimes quite intrusive. For example, Fievel is being pushed through the snow by one cat towards another, they added a train whistle sound. I know this is a cartoon, but that sound was not there originally, and it is inappropriately zany.
Also, there is additional walla and background "human world" dialogue. When we track in on the house at the beginning, you can hear laughter from the human inhabitants which spoils the music. When that lady in the apartment changes the cylinder in the gramophone, you can here a background conversation that was not in the original mix. Also, the frightened "A mouse!" screaming is different, and again more cartoonish, like something out of Tom and Jerry.
There is additional ADR that is by main cast members, so that was obviously recorded during production, but again, it is an alteration.
The most infamous change are the three orphans who taunt Fievel late in the film. In the original mix, their voices are either by kids or sound appropriately childlike. In the remix, they are clearly adults, and the actual lines are different. The most egregious difference (for many) is that as they are laughing at them, the one orphan doesn't chime in "Pit-ee-ful!"
However, most critics of this mix are wrong on one thing: they were not newly redubbed. The "new" voices are, in fact, the original tracks that the animation was synched to - the DVD version matches the mouth movements and the original mix doesn't. During post, they replaced the adult voices (Don Bluth's crew members, maybe?) with the ones heard in the final '86 mix. "Pitiful" may have even been an adlib by the kid brought in to redub the voice.
Who'd have thought this movie would have such an unfaithful remix? Fortunately, in this case the HDTV version is the original stereo from '86.