If you don't have Tatooine in the prequels, how do you resolve it with the OT? Do you give any indication as to who Owen is or is he just random guy who shows up in OT?

If you do have Tatooine in the prequels, how do you make it interesting and relevant to the story you're telling?

OT quotes to tackle:

Obi-Wan: Uncle Owen "didn't hold with your father's ideals. Thought he should have stayed here and not gotten involved."

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Obi-Wan: Uncle Owen "feared you might follow old Obi-Wan on some damn fool idealistic crusade, like your father did."

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Aunt Beru: "Luke's just not a farmer, Owen. He has too much of his father in him."

Uncle Owen: That's what I'm afraid of.