In my conception of the prequels, Anakin is actually Beru's brother, with Owen as his brother in law (hence why the two have different last names). Anakin's goodbye to Owen is very tense, especially with Lars pointing out that Skywalker is walking away from a pretty good thing (which Tatooine would seem like at this point) and from his family to pursue some foolish quest with some crazy wizard. Beru has mixed feelings, understanding why Anakin wants to leave, but thinking he'll be safer on Tatooine. While perhaps not said literally, Owen makes it pretty clear he's in no hurry to see Anakin again. (Leaving his family haunts Anakin later).

Then, when we see Owen years later, he's already bitter that his potentially good life on Tatooine has been ruined by the war, but with all they've put into it, he and his wife can't really leave. He's really angry that Kenobi took Anakin away, but Beru does convince him that they can at least look after Luke. Owen makes it clear that he will not let Kenobi ruin the life of Anakin's son and for Kenobi to stay away from them for good.