Well i lost my Grandfather and great Uncle to the disease so i have personal reasons for taking it very seriously, My only surviving grandmother and grandparent is also legally blind and cannot walk without help because she suffers from it.
On Lucas i also believed George's mother suffered from it though they never knew what her illness was in those days. She was always bedridden and sickly, he was mostly raised by his nanny Till and his dad was almost always at work at LM Morris company.