I'm currently reading the phoenix arc. which is what 'Last Stand' sort of took from a little, I guess. then I'm planning on skipping to uncanny number 475. I hear that's a decent spot to start.
Those indy comics look interesting. and Jhonen Vasquez is awesome. I loved Invader Zim when it came out.
Also, I forgot to mention Scott Pilgrim. Sure I read it because of the film hype but it's real close to my sense of humor. I recommend that too.