Haha, so I sat down to play Assassin's Creed II and there is no voice audio (I just missed the "It's a me Mario" line, I think). Really weird, tried a bunch of thing and can't get it back. Lousy glitchy game.
For a story based game, it really is pants to play it without any dialogue. Unfortunately, scouring the web for solutions given to others that have had this problem, I found they've all gotten really useful suggestions like, "Unmute your TV", "Try buying your games next time instead of pirating them!", "Delete the .iso you downloaded and BUY THE GAME." Hate the internet, way too many idiots.
Finding absolutely nothing helpful online. Well, I guess that is the end of Assassin's Creed II for me.
EDIT: Well, spent even more time searching and I am officially giving up. Google searches show that a lot of people have had the problem, but they usually just get flamed for it and/or accused of piracy or of being stupid. No solutions given, no fixes, nothing, but it seems to a problem across all three platforms, PC, PS3, and 360, only not a common enough problem for Ubisoft to have bothered with a patch or even for cleaver fans to have figured out a solution.
Soooo, hopefully I can at least get a few bucks for this POS game by selling it on amazon.