Thanks for the jumpstart, Frink! First to adapt your list, then I'll add a few in as I remember them.
X denotes that I beat/finished the game.
- denotes that I shamefully never played this game, and I regret it to this day.
Classics/Early Arcade:
Pac-man
Space Invaders
Dig Dug
Donkey Kong
Pong
Tron
Tron Discs
Spy Hunter
Star Wars (wireframe arcade)
Lode Runner
Defender
Frogger
Ms. Pac-Man
Frogger
Missile Command
Galaga
Asteroids
Atari 2600:
Pitfall
Pitfall 2
Food Fight
Burger Time
X Adventure
E.T.
River Raid
Raiders of the Lost Ark
80s PC:
Donald Duck's Playground
ZZT
Rogue
X Space Quest 1-3
- Loom
- Zak McKracken and the Alien Mindbenders
X Indiana Jones and the Last Crusade the Graphic Adventure
Indiana Jones and the Last Crusade the Action Game (Grr...! So close to finishing this one!)
X Mean Streets (Tex Murphy #1)
NES:
Duckhunt
Excitebike
Gauntlet
Gauntlet II
X Super Mario Bros
Super Mario Bros 3
Legend of Zelda (barely)
X Metroid
Batman (1989)
SNES:
X Super Mario World
X Super Metroid
X Flashback
Super Star Wars
Super Empire Strikes Back
Super Return of the Jedi
Other Arcade:
Xenophobe
Street Fighter 2
Mortal Kombat 1-3
X Die Hard
90s PC:
X Commander Keen 1-6 & Keen Dreams
Space Quest V
X Wolfenstein/Spear of Destiny
(The Space Wolfenstein)
X Martian Memorandum (Tex Murphy #2)
X Doom
X Fade to Black (Flashback 2)
X Quake
X Quake 2
X X-Wing
- TIE Fighter
- X-Wing Vs. TIE Fighter
X Legend of Kyrandia 1-3
X Star Craft
X Brood War
Sim City 2000
X 7th Guest
X Myst
X Under a Killing Moon (Tex Murphy #3)
X The Secret of Monkey Island
X Special Edition
X Monkey Island 2: LeChuck's Revenge
Special Edition
X Indiana Jones and the Fate of Atlantis
X Maniac Mansion 2 - Day of the Tentacle
X Full Throttle
X Wing Commander
Secret Missions 1 & 2
Wing Commander 2
- Specials Ops 1 & 2
X Wing Commander 3
X Pandora Directive (Tex Murphy #4)
X Wing Commander 4
Wing Commander Armada
Wing Commander Academy
X Privateer
X Righteous Fire
X Wing Commander Prophecy
X Riven (Myst #2)
X Sam and Max Hit the Road
X Grim Fandango
X Curse of Monkey Island
X Tex Murphy Overseer (Tex Murphy #5)
- The Dig
- System Shock
- System Shock 2
N64:
X Mario 64
- Rogue Squadron
X Legend of Zelda: Ocarna of Time
X Legend of Zelda: Majorka's Mask
- Perfect Dark
GBA:
X Metroid Fusion
Castlevania Aria of Sorrow
2000s PC:
X Escape from Monkey Island
- Starlancer/Freelancer
X Deus Ex
X Deus Ex 2: Invisible War
X Enter the Matrix
X Spider-Man (2001)
X Spider-Man: The Movie: The Game
X Hulk
X2 Wolverine's Revenge
X Star Wars: Republic Commando
X Prince of Persia: Sands of Time
X Splinter Cell
Myst III (Almost done?)
- FarCry
- Tales of Moneky Island (which I own, but am waiting to finish playing through 1-4 with the wife)
Xbox:
X Halo CE
X Halo 2
X Batman Begins
X X-Men Legends
X X-Men Legends 2
X Prince of Persia: Warrior Within
X Prince of Persia: Two Thrones
X Fable
X Chronicles of Riddick: Escape From Butcher Bay
Splinter Cell: Pandora Tomorrow (Didn't finish the last level because I wanted to start Chaos Theory)
Splinter Cell: Chaos Theory
Advent Rising
X Matrix: The Path of Neo
X Simpson's Hit and Run
X Hulk: Ultimate Destruction
X Spider-Man 2
X Ultimate Spider-Man
X XIII
X LotR: The Two Towers
X LotR: Return of the King
Xbox 360:
X Call of Duty 2
X Oblivion
- FallOut3 & DLCs
X SW: Force Unleashed
X Crackdown
X Prince of Persia (7)
X DLC
X Bioshock
X Bioshock 2
X Protector Trials
X Minerva's Den
X Assassin's Creed
X Assassin's Creed II
X Left 4 Dead
Left 4 Dead 2
X Halo 3
X Halo Wars
X Halo 3 ODST
X Halo Reach
X Iron Man
X Incredible Hulk
Spider-Man 3
X Spider-Man Web of Shadows
X Braid
X Shadow Complex
X Kingdom for Keflings
X Banjo Kazooie: Nuts and Bolts
X Tomb Raider Legend
X Tomb Raider Anniversary
X Tomb Raider Underworld
X Lara Croft and the Guardian of Light
X Castlevania: Symphony of the Night
X Gears of War
Gears of War 2 (Grrr! My co-op buddy doesn't have time to finish this!)
X Batman Arkham Asylum
X Call of Duty 4: Modern Warfare
X DarkSiders
Fable 2
Mass Effect
Wii: (including some GC backwards compatibility)
X Metroid Prime
X Metroid Prime 2: Echoes
Mario Sunshine
- Zelda Windwaker
- Zelda Twilight Princess
Metriod Prime 3: Corruption
Wii Sports
X WarioWare: Smooth Mooves
WarioLand: Shake It!
Super Mario Galaxy
Boom Blox
Boom Blox 2
Speed Racer
New Super Mario Bros. Wii
Epic Mickey
PS3:
X Uncharted: Drake's Fortune
X Uncharted 2: Among Thieves
X inFamous
Flow
Flower
Trine
X Little Big Planet
Resistance: Fall of Man
Should I keep going?
MOAR.