I really loved that show. And really, really, really, really wanted a worthwhile ending to make it all worth it... and unfortunately the ending was pretty awful... the whole last season was pretty awful... but the ride there was still a lot of fun.
A lot of disappointments with things you think ought to have been explained left unexplained, and stuff that should have been left unexplained given entire episodes dedicated to their over explanation.
I think in the end overall I'd still have to say it is a sci-fi show that is extremely worthy of watching your way through at least once... just so long as you don't expect too much out of it.
At times I can't help but wonder how great the overall show could have turned out had it been made in a age prior to the internet and instant fan feedback. Some of its biggest stumbles along the way seems to have been from trying to cater to fans (Nikki and Paulo, Jack's tattoo episode, etc.) and from trying to dodge fan speculation by continually changing the direction of the story.