At first I wasn't really sure what you meant, But now that I've taken a look I have to say I'm all for it. I've also thought aout this sort of thing before, I toyed with various panels from the Reversal of fotune strips on hyperspace. but never really made anything of worth.
Are you planning on keeping text balloons? - Just wondering if you'd stick with whats there or go with subtitles. I supose it may depend on what sources you have to work with.