Gross - Budget = Unadjusted Profit
I say "unadjusted" because there are undoubtedly other expenses (marketing, etc.) that come into the equation, but sometimes the information just isn't there. To make this applicable to the current time, I've also adjusted all numbers for inflation.
Raiders of the Lost Ark
Budget: $44,158,273.38
Gross: $588,462,276.46
Profit: $544,304,003.08
Indiana Jones and the Temple of Doom
Budget: $56,833,333.33
Gross: $365,093,823.88
Profit: $308,260,490.55
Indiana Jones and the Last Crusade
Budget: $82,458,438.29
Gross: $338,718,316.60
Profit: $256,259,878.31
Stiff competition. I wonder if the downward profit trend will continue.