For example, I did experience few times a problem related to texel alignment. I have a GeForceFX 5600 Ultra right now (don't laugh), the current drivers won't allow me to adjust texel (in the center or in the corner) just like I used to do it on my old RivaTNT-based card (even the fan-made tweaking proggy didn't help). Without this fix there may be problems with textures on some older titles and often game text will be "garbled"(e.g.: Darkstone). This is true in the case of Star Wars Rogue Squadron 3D and X-Wing Alliance. Luckily for me, there is some fan-made fix for X-Wing Alliance, just as some people try to patch Populous 3 (which also gives me blinking and warped interface textures).
tiefighter, are you by chance a flight sim fan? I'm infering this from the joystick types you've collected: Thrustmaster FCS/WCS surely isn't built for arcade shooters
I know because I used to have this combo 
Too bad we live so far from each other, I'd send you my old gear if you had any need for spare parts - but I guess this thing isn't worth its dead weight now, LOL (I was saving them for my old buddy, who used to make custom modifications to flight sticks).* * *
While we're speaking about running old games on new systems, I thought it would be nice to remind people reading this thread about a useful website - this forum often saved me a lot of trouble finding myself the way to launch a given old game.
VOGONS - Very Old Games On New Systems
Right now I'm finishing last touches to revive my old Warhammer - Shadow of the Horned Rat. This was the game that forced me to switch to that new Windows 95 thingie, imagine that!