Growing up, Zelda, Metroid and Mario1 and 3 were highlights of the NES.
LttP, Super Metroid, f-zero on SNES
Turok 2, Goldeneye, Rogue Squadron, Podracer, Mario 64, Ocarina of Time (although I still feel that this game held you by the hand too much and kinda cheapened it for me.) for N64
Can't say much about the cube...I totally skipped this past generation.
DS: Advance Wars DS: I have never spent so much time on one game as I have with this one. Just pure crack. I love it!
Maybe in a year, I'll get a Wii.