Samueal L. Jackson is an FBI agent, transferring a mafia informant across the country to testify. The mob, however, manages to sneak 300 deadly snakes on board the plane they are flying and hilarity insues.
Ok, so I made those last 3 words up, but you never know. The way everyone here was talking about it, I thought it was some kind of joke at first. Then I saw it on this list.