To me, it seems to be a statement about mainstream Christianity's seemingly blind and unwavering endorsement (if not outright campaigning) of the Republican party over recent years and the current neo-conservative administration they helped to power.
Not saying I agree with it. That's just what I read into it, since it IS meant to be a political cartoon, and obviously, artwork of that type tends to have an underlying message, hence the point. Granted, it's put across in very crude and inflammatory terms, but I assume that's keeping in tone with the artist's style and with rest of the series. There is truth to the cartoon, depending on your point-of-view.
Do I understand why some people are offended? Yes. Am I offended? No. Because I was taught in middle school that characters in political cartoons should not be understood as they appear overtly, but rather, as what they represent.
And is it okay for radical Muslims to burn down cities, kill people, and disrupt the economy of all of Denmark over one cartoonist's political views? Absolutely not. Anymore than it's okay for radical Christians to get worked up over this. For one thing, both Christ and Mohammed taught tolerance. And for another, it's not socially acceptable.
Can't understand why people can't just see something they don't like, shut their eyes and walk away. But no, it's gotta be "I'm right, you're wrong, let's have a culture war and set everything ablaze!"