Guilt over isolation? At the moment, I have to say not a chance.
The computer lab where I work is segregated from the rest of the library...much of the time I only see coworkers when I leave for dinner or if there is a problem with a computer in another part of the library.
When I'm at home, my family knows to let me alone unless its time to eat.
However, past experiences forge future reactions. Perhaps at some point in the future, I won't be able to say that.