Thus far I’ve yet to encounter anything in the prime universe I’d disregard as non-canon.
Oh if you only knew…
Well let’s get down to business.
TOS
TAS
IDWY4
Y4TEE
WEAT
STC
TMP-TUC
TNG
DS9
VOY
ENT
LDS
And that’s it for the Prime Timeline. As much as I enjoy First Contact, I’m more than willing to sacrifice it so that TNG ends definitively with All Good Things.