Why would he ask if she’s safe and then immediately dismiss it?
I think if you wanted to get that point across it would be better to just not address the Padme situation at all.
The idea is that Vader’s reasoning is more or less like this: “Is she alive? Then I’ll keep her at my side and force her to agree with me. Is she dead? Then I can do without her.” Indeed, we see Vader reasoning like this already when he is on Mustafar, when he tells Padmé to join him and basically has no problem choking her. The Dark Side has twisted his mind so much that he no longer sees Padmé as a person, but as a mere object that he can use the way he sees fit.