For anyone who’s interested: I’ve found what I think are the best settings to minimize the interlacing/telecine problem with Futurama. It’s not perfect, and if I had all the time in the world to go in and manually correct each frame, it would certainly look better, but… here’s what I was able to accomplish with automatic settings: https://ibb.co/z5B0fnb

As you can see in the screenshot, for those frames that are affected by the jaggies, this filter combination seems to really minimize the appearance. And of course, the non-jaggy frames look very good. (See here: https://ibb.co/NYLNLWd)

Once I’m finished upscaling all the episodes, I’ll update this thread. In the meantime, if anyone has better versions of the episodes that I can work with, please let me know.