Set in the 26th century, the story takes place 300 years after a societal collapse caused by a major war. In that society, it's a technological dark age following a pinnacle of achievement far beyond where we are right now. Cyborg technology is a way of life. People are augmented a lot as workers, so being a cyborg is not unusual. The main character is a cyborg. She has an organic human brain, and she looks like she's about fourteen years old. She has a completely artificial body and she's lost her memory. She is found in a wreckage and reconstituted by a cyber-surgeon who becomes her surrogate father.
If it pays off, do you think it'll inspire a trend of live action anime films in Hollywood for the next few years (though there have been some anime imitators in the form of The Matrix Trilogy and Dark City). For all anime fans here, list anime you'd like to see done up as live action films. My list -
1) Bubblegum Crisis Tokyo 2040 - women with combat suits and lots of property damage, what more could you ask for?
2) Dominion: Tank Police
3) Gunsmith Cats
4) Slayers