Going on the assumption that you are muxing the DVD audio stream with the Blu Ray video stream, it looks like that you are going to have to apply a forward delay of 4 seconds on the DVD audio track. In either MKVToolNix or TSMuxer, there’s a delay box where you apply the value, expressed in milliseconds. First, you need to know how much delay that you need to apply.
Open your muxed file in the media player, VLC, and use it to search for the delay value to put in the delay box. Go to the point of the film where the 1st line of dialogue is spoken. Select the audio stream to set your delay–press the ‘J’ key to nudge the audio stream forward, press the ‘k’ key to nudge it backward. When you find the right sync, write the delay-value down. Now go to the end of the video where the film’s last line of dialogue is spoken. If the audio is sync’d with that scene, then this step is over and you are ready to re-do muxing of the two streams together where you are going to apply the delay value in the delay box.