Personally, I’ve had good luck using Handbrake to detelecine the DVD rips to 720x480 square-pixel lossless CFR 23.97fps h264 mp4s, and then running Topaz VEAI’s Dione Interlaced Robust V3 on them. The great thing about this model is that it keeps the majority of the detail while making things a little cleaner and sharper. It never massively blurs any areas of the image, like Artemis has a tendency to do, nor does it have the lengthy processing time of Gaia. It also sorts out the occasional interlacing artifacts left in my detelecined rips (which are usually the result of post-process screen shake). Other models tend to exaggerate them instead. The only big downside is that the sharpening causes the image to lose a little of its perceived depth - but that’s not so noticeable in motion, at TV-distance.
Here’s images of the Defiant, the Station, the Replimat, and the Sisko.