I still don’t like the idea of midichlorians. From the OT we knew there was a likelihood of Force wielding abilities being inherited, but it was never so explicitly made scientific. There was a mysteriousness about it all.
The closest I can think of right now is Thor’s hammer, Mjolnir. If you’re worthy, you can lift it. It implies that even if you’re not worthy now, you can work to improve yourself and eventually become worthy. If they made some sort of biological explanation to it, well it says you’re just plain not worthy and never will be, no matter how much you try.
Not saying everyone should be able to use the Force, but at least don’t make it come down to a blood test. Either leave it mysterious or let it be something very difficult to attain. Worthy traits are often inherited, but are not the be all end all.
I still like the prequels though.