Regarding The Orville, I recently heard a theory which posited that since Seinfeld exists as a TV show in the Orville universe (the crew was watching it on the main viewer), and Star Trek exists as a TV/Movie series in the Seinfeld universe (Jerry and George talking about Spock’s death in Wrath of Khan), that Star Trek also exists as a TV/movie series in the Orville universe.
Seth MacFarlane was directly asked about it at a panel, but he said he couldn’t answer that in a manner that would satisfy anyone.