I’ve not seen much Paul Rudd comedy. I saw him in Halloween 6 and he was just hilarious so maybe I should check out some more of his work.
The joke is that whenever he’s on Conan to advertise his new films, he plays a clip of Mac and Me in its place. The same clip, Every Time. There’s even a couple episodes where he gets them to play it twice in a row.
Here’s a compilation of the times he’s done it https://www.youtube.com/watch?v=6bNzAgJMYVE