With Trump in office, I keep hoping liberals will see the danger of consolidation and expansion of federal power. Some wonder if marijuana could be the gateway drug to federalism.
If Federalism’s most notable appeal is that it can throw a wrench in the gears when the Federal Government opts to do spectacularly bad things, the argument is already lost IMO. Because, among other things, who can throw a wrench into the gears when states opt to do spectacularly bad things? Whoever gets primacy gets the ability to screw people over, any good anarchist could tell you that.
That said, liberals AFAIK have never been against Federalism per se, but see the role of the Federal goverment fundamentally differently than conservatives. There’s plenty of good stuff in Federalism, liberals just hate most of the things conservatives love about it, and vice-versa.