It bugs my bones that Americans associate separatism with white supremacist ideals and slavery. I wholeheartedly believe that sooner rather than later this country will split into an increasing number of successor republics. I am certain that some of those, particularly the states that emerge in the Southeast, will be pretty much like apartheid states, even more so than the US is currently. However I would expect better of the states that arise in the North and the West.
Tl;dr, some Americans want to secede for non-shitty reasons.