Burying the originals is obviously George’s worst decision, but at a close second I would say his decision to shoot AotC and RotS on measly 2/3" digital cameras long before that technology was ready (it’s only in the last four or five years that we’ve gotten digital cameras that even come close to replicating the look of actual 35mm cinemascope) and his obsession with green screen and cgi in general.
I also want to say “directing the prequels himself,” but it’s hard to blame him for that when he offered the job to his friends (Howard, Zemeckis, et al) and they all turned it down saying George should do it. I guess it’s all their fault!
Then there’s the creation of the Special Edition, which ultimately should never have happened, but a world where the SE never happened kind of goes hand in hand with a world where George successfully handed over the PT to other directors (or at least directed it himself without going digital crazy).