I’ve never seen it (or heard of it before now), so I can’t really say a lot. Based on the Wikipedia article, nothing looks particularly objectionable, although I see some things that could be, depending on how they’re portrayed.
Have you seen it at all? If so, are there any specific parts that you’d be curious about? It does seem unlikely that there would be the level of corruption among cardinals that the article mentions, but it is possible. I also object to the idea of “conservative” vs. “liberal” Catholicism. Although I know what is meant by that, I disagree with the use of the terms (that’s a sidenote though, it doesn’t really have much to do with the show).
EDIT: It looks interesting, though. I’d love to have a discussion about some of the issues it references.